6 min read

Your skin cells take instructions. Build collagen here, close this wound, make new cells. Growth factors are the messengers that carry those instructions, and your skin sends fewer of them every decade. That decline is a large part of why skin gets thinner and slower to bounce back.

The short answer

Growth factors are signaling proteins that tell skin cells to produce collagen and repair themselves. Applied topically, they supplement the signaling that declines with age, and studies show improvements in fine lines, firmness and skin texture over about three months. They are gentle, they suit skin that cannot tolerate retinoids, and they are one of the best things to use after a treatment.

Suits All skin types, Mature, Sensitive, Dry, Normal
Read time 6 min
Diagram showing growth factor proteins fitting receptor notches on a skin cell like keys in locks, prompting the cell to make collagen.
Each growth factor fits a specific receptor like a key in a lock, and the cell changes what it is doing in response.

What it does

Growth factors are signaling proteins that tell skin cells to produce collagen and repair themselves. Applied topically, they supplement the signaling that declines with age, and studies show improvements in fine lines, firmness and skin texture over about three months. They are gentle, they suit skin that cannot tolerate retinoids, and they are one of the best things to use after a treatment.

What a growth factor is

A growth factor is a protein that carries a specific instruction from one cell to another.

It works like a key in a lock. Each growth factor fits a particular receptor on the surface of a cell, and when it docks there, the cell changes what it is doing. Divide. Make collagen. Build new blood vessels. Move across and close this wound.

Different growth factors carry different instructions. EGF, which stands for epidermal growth factor, tells surface cells to renew. TGF-beta is heavily involved in collagen production. VEGF works on the small blood vessels that feed your skin.

A serum usually contains several, because repair is a coordinated job rather than a single command.

Why this is different from most anti-aging ingredients

A retinoid works partly by irritating your skin into renewing faster. The irritation is not a side effect, it is part of the mechanism, which is why using one involves weeks of adjustment.

Growth factors ask your cells to do something instead of forcing them. Nothing is being provoked, which means there is nothing to build tolerance to and nothing to get through. That is the trade: more comfortable, and slower.

Getting a protein that size into your skin

It is a fair question, because growth factors are large molecules and your barrier is built to keep large molecules out.

This is the problem a good formula is designed to solve. Growth factors are commonly encapsulated in liposomes or similar carriers built to ferry a large protein through the surface, and research on these delivery systems shows they measurably improve how much gets in. A product that has invested in one will usually say so on the packaging.

Some of the effect also comes from signals passing onward. Growth factors acting on the upper layers prompt those cells to send their own messages deeper, because your skin cells pass instructions to each other in turn.

The microneedling exception

Growth factors work well alongside lasers and peels, and they are useful in the days after microneedling too. What we do not do is apply them immediately after a microneedling session.

Your skin is already flooding the area with its own growth factors at that point, which is precisely how microneedling works. Adding more achieves nothing. We wait about forty-eight hours, and from there a growth factor serum becomes part of supporting the healing.

Where growth factors come from

Your own cells make them. Fibroblasts, keratinocytes and others release growth factors constantly to coordinate repair and renewal.

The ones in skincare are grown rather than harvested. Cells are cultured in a lab and either the growth factors they release are collected, or the proteins are produced directly through recombinant technology, which means an identical copy made without needing the original cell.

On an ingredient list these appear as sh-Oligopeptide or sh-Polypeptide followed by a number, where the sh simply means it matches the human version. Some products use conditioned media instead, which is the whole fluid the cultured cells released. Both approaches work.

Diagram showing three growth factors and the different instruction each one carries: renew surface cells, make collagen, build blood vessels.
Different growth factors carry different instructions, which is why a serum usually contains several.

What to look for on a label

Human-derived and plant-derived are different ingredients

Nearly all the research behind growth factors was done with human ones, produced either by culturing human cells or by recombinant technology. On an ingredient list those appear as sh-Oligopeptide and sh-Polypeptide, where the sh simply means the protein matches the human version.

Plants have their own growth factors, and they are a different material sharing the same name. Human skin cells have no receptors built to read plant signals, and the evidence that plant-derived versions do anything comparable is thin at this stage.

What that means practically is to check which one you are buying, because the two are priced and marketed similarly. If the source is not named on the packaging, ask.

Ask how it gets into your skin

Getting a large protein through intact skin is the central problem with this ingredient, and how a product solves it is worth knowing before you buy.

You will not always find that on the packaging, and it is a fair thing to ask a brand directly. A company that has invested in the technology will be glad to tell you how theirs is designed to work.

Several beats one

Repair is a coordinated process, which means a serum with a blend of growth factors generally does more than one built around a single protein. Many good formulas also add peptides, which are smaller signaling fragments doing a related job, and antioxidants to protect the result.

Packaging is not a detail

Growth factors are proteins, and proteins are fragile. Heat, light and air degrade them, so airless pumps and opaque bottles are what you want. An open jar is the wrong format for this ingredient, and a bottle that has sat in a warm bathroom for a year will be doing less than it did.

Where it sits in your routine

Most growth factor products are serums, which go on after cleansing and before your moisturizer. If yours comes in a cream, that is your moisturizer step.

What works best with growth factors

Growth factors conflict with nothing. They pair particularly well with a retinoid, since one asks your cells to build while the other speeds up turnover, and plenty of people use growth factors in the morning and their retinoid at night.

Sunscreen every morning, reapplied through the day. There is little point asking your skin to build collagen while UV breaks it down faster than you can replace it.

Common questions

Growth factors or exosomes?

Cousins rather than rivals. A growth factor is a single signaling protein applied on its own. An exosome is a sealed package that carries many signals at once, growth factors among them, with a membrane that protects the cargo.

Growth factors have a much longer track record, more consistency from product to product, and clinical studies going back over twenty years. Exosomes carry a richer message and vary more between products. Both are good ingredients, and if you want the better established of the two, this is it.

Growth factors or retinoids?

Retinoids have more evidence behind them and remain the stronger single choice for anyone who tolerates one. Growth factors are the more comfortable option and work by a completely different route, which makes them an excellent alternative if retinoids have not suited you, and a good partner if they have.

When do I use them around a treatment?

With lasers and peels, use them through the healing period as your provider advises.

With microneedling, wait about forty-eight hours before going back to your growth factor serum. Your skin is producing plenty of its own in the immediate aftermath, so there is nothing to add until that settles. If you are a client at our New York City LAZ Clinic, ask us and we will tell you exactly when to start.

How soon will I see something?

Twelve weeks. This works on collagen, and collagen does not hurry. Most of the studies measured at three months, and skin texture tends to improve before firmness does.

Growth factors do not come with the signs you might associate with an active ingredient working, the way a retinoid brings peeling. The work happens quietly, which is why the photographs matter.

Can they make anything grow that should not?

This question comes up because growth factors are involved in cell division, and it is a fair thing to wonder.

The reassuring part is that topical growth factors act on the upper layers of skin, and they are proteins that break down rather than accumulate. There is no evidence linking topical growth factor products to any such risk. If you have a personal or family history that makes you cautious, that is a conversation worth having with your doctor.

Can I use them in pregnancy?

Skincare ingredients are almost never tested on pregnant people, for obvious ethical reasons, so a definitive answer does not exist for growth factors or for most things. What we can tell you is that plenty of people carry on using them through pregnancy without concern. Ask your OB or midwife and go with what they say.

Are they vegan?

Recombinant growth factors are produced without animals, though they are copies of human proteins, so whether that meets your definition is a personal call. Products using cultured human cells are similar. Worth checking the specific product if it matters to you.

Timeline showing a forty-eight hour wait after microneedling before resuming a growth factor serum, because your skin floods the area with its own.
Your skin is already flooding the area with its own growth factors. Adding more achieves nothing until that settles.

How to use it

  • Once or twice daily on clean skin. Most growth factor products are serums, which go on before your moisturizer. If yours is a cream, it takes the place of your usual one.
  • No building up needed. There is no tolerance to develop and no irritation phase to get through, so you can use it daily from the start.
  • If you use a retinoid, growth factors in the morning and the retinoid at night is a comfortable arrangement.
  • Around lasers and peels, use them through the healing period as your provider advises.
  • After microneedling, wait about forty-eight hours before restarting. Your skin is producing plenty of its own in that window.
  • Follow the storage directions on your packaging. These are proteins, and heat and air degrade them, so most need keeping somewhere cool and dark with the bottle closed.
  • Broad spectrum SPF 30 or higher every morning, reapplied through the day.
  • Photograph your skin on day one and every four weeks, in natural daylight from the same spot, and give it twelve weeks.
Evidence and sources

A note on the evidence. Growth factors have a longer research history than most of the newer actives, with clinical studies going back over two decades and consistent findings on fine lines, texture and firmness across about three months of use. The biology is not in question either, since their role in wound healing is thoroughly established. Two honest limitations remain. Many of the studies are small and some are funded by the companies selling the products, and the question of how much of a large protein actually penetrates intact skin has never been fully resolved, which is part of why the results after a treatment are clearer than the results without one.

Last reviewed

Products with Growth Factors

  • Plated

    Calm Serum

    5.0 out of 5.0 stars

    $258.00

    A watery exosome serum that soothes irritation, strengthens the barrier, and calms redness and sensitivity.

    If you’re struggling with redness, rosacea, barrier damage, or sensitivity, Calm Serum is our go-to. It instantly soothes irritation, helps strengthen the barrier, and makes reactive skin feel more balanced. We recommend it post-procedure too, since it helps calm and comfort the skin while supporting recovery.

    Laziza SFounder & Head Esthetician

    Calm Skin. Restore Balance.

    The Calm Serum is designed for skin that needs a reset. Whether you are dealing with redness, irritation, sensitivity, or flare-ups after procedures, this soothing formula helps restore a healthier-looking complexion and delivers fast relief while working to strengthen your skin's barrier over time. Beta glucan adds soothing, hydrating, and barrier-strengthening support.

    Powered by Platelet Science

    This serum features plated's proprietary Renewosome technology, exosomes enriched with over 800 growth factors and anti-inflammatory cytokines. These bio-identical messengers help signal repair, reduce irritation, and support your skin's natural healing processes, especially when it is under stress. Amino acids, the building blocks of collagen and elastin, add hydration and help protect the skin barrier.

    Gentle Enough for Reactive Skin

    Every detail of this serum is crafted for tolerance and comfort. It is fragrance-free, non-comedogenic, and tested for sensitive skin. With a silky, non-greasy finish, it layers easily into any skincare routine, even after in-office procedures or during barrier repair protocols. Apply it to clean skin as the very first step, before your hydrator.

    Long-Term Relief and Resilience

    Used consistently, the Calm Serum helps your skin become less reactive, with improved hydration and reduced flushing. It is ideal for anyone navigating rosacea-prone skin, chronic sensitivity, or skin that feels overworked or stripped. It is also a calming choice after professional procedures, supporting comfort and recovery.

  • Hydrinity

    CELTHERA Advanced Overnight Repair Cream

    From $20.00

    Overnight repair cream with growth factor technology, NAD+, seven ceramides, and Centella Secretome for renewal.

    If you want a moisturizer that works on signs of aging and barrier repair at the same time, Hydrinity CELTHERA Cream does both. It combines growth factors, peptides and barrier repair ingredients in one moisturizer, which is basically what we look for in an anti-aging moisturizer. The texture is medium, not heavy and not too light. It is formulated not to clog pores, and your skin feels comfortable without feeling greasy. If your skin is very oily and you prefer a gel, this may feel richer than you want in summer.

    Laziza SFounder & Head Esthetician

    Supports Cellular Repair and Renewal Overnight

    CELTHERA pairs overnight hydration with ExoEGF Technology, a biomimetic exosome system that delivers Oligopeptide-1, a growth factor that supports cellular communication and energy production in the skin. While you sleep, during the skin's natural repair cycle, it helps signal cells to renew more efficiently for visibly improved texture, firmness, and radiance by morning.

    NAD+ Support Restores Cellular Energy and Skin Vitality

    Cellular energy drives every process that keeps skin looking healthy, from collagen production to barrier repair to overnight renewal. As NAD+ levels decline with age, these processes slow down. Sunflower Sprout Extract in CELTHERA supports NAD+ production in the skin, helping restore the energy that powers overnight repair, so skin wakes up looking more rested, resilient, and radiant.

    Centella Secretome Rebuilds Collagen and Calms Inflammation

    Inflammation is one of the most underestimated drivers of visible aging. Chronic low-grade inflammation breaks down collagen, disrupts barrier function, and accelerates the accumulation of discoloration and texture changes. The Centella Secretome Stem Cell Concentrate in CELTHERA addresses this directly while simultaneously supporting collagen and elastin remodeling. Skin becomes progressively calmer, firmer, and more even-toned with consistent overnight use.

    Multi-Ceramide Barrier Blend Seals and Protects

    CELTHERA's Multi-Ceramide Barrier Blend combines seven ceramides with essential fatty acids to rebuild the barrier's structural foundation, while the ExoEGF Technology and growth factors work on cellular renewal beneath it. This dual approach supports the barrier and cellular renewal at the same time, and skin that uses it consistently becomes more resilient over time.

  • Lumisque

    CO2Lift Carboxy Mousse Moisturizer

    4.8 out of 5.0 stars

    Sale price $225.00 Regular price $249.00

    Hydrates, soothes, and enhances radiance with the skin-revitalizing benefits of carboxy therapy.

    If you have acne, PIE/PIH, slow healing, redness, melasma, pigmentation, or texture concerns, thie Carboxy moisturizer is such a good fit. It helps calm inflammation, brighten uneven tone, support healing, and keep the skin hydrated and balanced without feeling heavy. All the good stuff your skin needs, in one step.

    Laziza SFounder & Head Esthetician

    Lightweight Hydration, Powerful Rejuvenation

    CO2Lift Carboxy Mousse Moisturizer delivers deep hydration in an airy, mousse-like texture that instantly refreshes and revitalizes the skin. Designed for daily use, this moisturizer supports skin barrier health, calms inflammation, and promotes radiance, making it ideal for all skin types, especially those seeking glow without heaviness.

    Inspired by Carboxytherapy Science

    Infused with CO2Lift’s proprietary oxygen-boosting technology, this moisturizer mimics the skin-rejuvenating effects of carboxytherapy by encouraging circulation and cell turnover. The result? Smoother texture, visibly brighter tone, and improved elasticity over time, all with a weightless, breathable finish. Apply a dime-sized amount to areas of concern, wait 60 seconds, then spread the rest over the face and neck.

    Soothes, Plumps, and Protects

    Formulated with antioxidants, amino acids, and calming agents, Carboxy Mousse works to reduce redness, soften fine lines, and support collagen integrity. It is especially beneficial for post-procedure skin, sensitive types, or anyone looking for gentle yet effective anti-aging benefits. Sodium hyaluronate draws moisture into the skin’s layers to keep it supple and plump.

    Ideal for Morning and Night Use

    This mousse glides on effortlessly and absorbs quickly, making it a perfect final step in your skincare routine. Use it after serums or other active steps to lock in moisture without clogging pores or leaving behind residue. Skin is left hydrated, balanced, and visibly more luminous. It also suits skin managing breakouts, post-acne marks, or uneven tone.

  • Plated

    Daily Serum

    4.9 out of 5.0 stars

    From $244.00

    A gel exosome serum that prevents fine lines, boosts glow, and supports daily skin renewal.

    If you’re starting to notice early signs of aging like dullness, fine lines, or just need a boost for glow, Daily Serum is such a good fit. The thicker gel texture feels amazing and really gives the skin that refreshed, bouncy look. Our clients love how it keeps their skin looking smooth and radiant with consistent use; it’s a perfect everyday anti-aging step.

    Laziza SFounder & Head Esthetician

    Everyday Repair That Works Harder

    Daily Serum is a dependable choice for healthy, youthful-looking skin, formulated to support skin repair, smooth texture, and reduce signs of aging with every use. It is gentle enough for daily application, yet powerful enough to address fine lines, dullness, and visible signs of stress. Its gel texture leaves skin looking refreshed and bouncy.

    Powered by Exosome Technology

    At the heart of the formula is plated's exclusive Renewosome technology, lab-engineered exosomes that deliver over 800 growth factors and anti-inflammatory cytokines directly to your skin. These biologically active messengers help mimic your skin's own regenerative signals, encouraging better repair and visible rejuvenation. Amino acids, the building blocks of collagen and elastin, help hydrate and protect the barrier.

    Strengthens and Smooths Over Time

    With continued use, Daily Serum helps soften fine lines, improve tone and elasticity, and fortify the skin barrier. The lightweight texture absorbs easily and layers well under other skincare and makeup, making it an ideal daily essential for both prevention and correction. Apply it first on clean skin and allow five to ten minutes to absorb.

    For All Skin Types, Every Day

    This formula is hypoallergenic, fragrance-free, and non-comedogenic, making it safe for all skin tones and types, including those with sensitivity or inflammation. Whether you are focused on age prevention or recovering from skin stress, Daily Serum helps your skin function and look its best. Glycerin draws in water to help maintain hydration and barrier function.

  • Pavise

    Extracellular Matrix Restore

    $278.00

    A regenerative formula that supports post-procedure healing and strengthens skin structure.

    We recommend the Pavise Extracellular Matrix Serum for recovery after all treatments, including microneedling. In the first few days after microneedling we avoid lipids, but starting around day 3+, when the skin often feels much drier, this is one of our favorite products to introduce. It helps keep the skin calm, supports collagen, and assists the rebuilding process while the skin is healing.

    One of the reasons we like this formula is because it contains growth factors. Growth factors are signaling proteins that help guide the skin to repair itself and produce healthier new cells, which makes them especially helpful during the regeneration phase after treatments like peels.

    Laziza SFounder & Head Esthetician

    Supports Skin Recovery After Procedures

    Pavise Extracellular Matrix Restore is designed to support the skin during recovery from aesthetic procedures. Acting like a bioactive second skin, the formula helps guide how the skin repairs itself, promoting smoother healing and a more balanced, comfortable recovery process. After microneedling, it can be introduced around day three, when skin is ready for supportive serums.

    Helps Rebuild The Skin’s Structural Network

    This formula focuses on supporting the extracellular matrix, the structural framework responsible for skin strength, elasticity, and resilience. Peptides, recombinant collagen, and growth factors help signal the skin to rebuild key structural components that support firmness and long-term skin integrity. Palmitoyl peptides support collagen production and help strengthen this matrix, while recombinant growth factors help signal regeneration.

    Improves Hydration, Firmness, And Skin Quality

    By supporting collagen production and hyaluronic acid levels, the formula helps improve visible skin texture and firmness. The combination of peptides, ceramides, and antioxidants also helps calm inflammation and reduce oxidative stress, allowing the skin to recover more efficiently and maintain a healthier appearance. Follow with a moisturizer if your skin feels dry.

    Ideal For Post-Procedure Skin And Advanced Repair

    Extracellular Matrix Restore is especially helpful for individuals undergoing professional procedures such as lasers, microneedling, or resurfacing procedures. It supports faster skin recovery while reinforcing structural repair, making it a useful addition to routines focused on skin regeneration and post-procedure care. It also suits recovery after peels, when growth factors help guide the regeneration phase.

  • Calecim

    Eye Contour Lifting Cream

    5.0 out of 5.0 stars

    $160.00

    Lightweight cream with PTT-6 that firms, lifts, and softens skin.

    We recommend the Calecim Eye Cream for anyone wanting to brighten and lift the skin around their eyes. It firms, smooths fine lines, and makes a noticeable difference within just a couple of weeks. We have seen it help with puffiness, dark circles, and more serious eye-area concerns, not just prevention. It’s one of our top picks for eyes that are already showing signs of aging.

    Laziza SFounder & Head Esthetician

    Targeted Renewal for the Eye Area

    The Eye Contour Lifting Cream is a scientifically advanced treatment designed to visibly lift, firm, and rejuvenate the delicate eye area. Powered by stem cell-derived proteins, it helps reduce the appearance of fine lines, puffiness, and dark circles, restoring a smoother, more youthful-looking contour with every use.

    Stem Cell Science for Brighter, Firmer Eyes

    Formulated with CALECIM’s patented Rejuvenating Conditioned Media, this cream delivers concentrated growth factors and peptides that signal skin to rebuild collagen and elastin. The result is stronger, firmer skin around the eyes with improved texture, hydration, and resilience over time. Hesperidin, a citrus bioflavonoid, adds antioxidant support that helps reduce the look of dark circles and redness.

    Lightweight Yet Potent

    The silky texture absorbs quickly without greasiness or heaviness, making it ideal for layering under makeup or other treatments. With regular use, the Eye Contour Lifting Cream helps lift sagging eyelids, smooth crow’s feet, and improve skin tone around the orbital area, without irritation or downtime.

    Trusted by Professionals

    Used by aesthetic clinics worldwide, this eye cream is often recommended post-procedure or as part of an anti-aging regimen. It is suitable for all skin types, including sensitive, and is free from fragrance, parabens, and unnecessary fillers that can irritate the fragile under-eye area. Cucumber extract adds a cooling, calming touch for sensitive or easily irritated skin.

  • Vivant

    FF3 Biointensive GF

    $294.00

    Growth factors, retinyl propionate, peptides and exfoliating acids that restore volume to skin with lower estrogen.

    If you are going through menopause or hormonal changes and your skin is starting to feel thin, dry, and like it has lost its bounce, this is genuinely one of the most complete products we have come across for that. You are getting vitamin A, growth factors, dual acids, five peptides, and Manuka honey all in one step. From our clinical experience, this type of skin responds incredibly well to growth factors because estrogen loss directly affects how the skin regenerates. It actively works to compensate for what the skin loses when estrogen declines. Clients consistently start getting compliments within 45 days and some say it replaced four other products in their routine. For menopausal and peri-menopausal skin, this is one of our top picks in the clinic.

    Laziza SFounder & Head Esthetician

    Cellular Reactivation for Estrogen-Depleted and Hormonally Aging Skin

    Vivant FF3 Biointensive GF is a clinically proven serum specifically formulated for estrogen-depleted, menopausal, peri-menopausal, and hormonally aging skin. Retinyl Propionate, growth factors, mandelic acid, lactic acid, five peptides, and Manuka honey work together to repair the skin's support matrix, restore lost volume, reduce fine lines, and transform dry, thinning skin into plump, smooth, and radiant skin. Acne safe and appropriate for all skin types.

    Growth Factors and Retinyl Propionate Restore Thinning Skin

    Skin that is thinning and losing structure due to hormonal changes needs support for both renewal and structure. Growth factors signal the skin's own repair mechanisms, while Retinyl Propionate, a vitamin A ester developed by Vivant founder Dr. James Fulton, delivers vitamin A's corrective benefits with minimal irritation. Together they support the renewal that hormonally aging skin requires.

    Plumps and Restores Lost Volume and Contours

    The visible hollowing, sagging, and loss of contour that come with hormonal skin aging reflect structural changes beneath the surface. FF3 Biointensive GF rebuilds this foundation through a combination of growth factors, five specialized peptides, and Retinyl Propionate that collectively stimulate collagen, restore hydration capacity, and support the structural proteins responsible for lifted, plump, and defined skin.

    Resurfaces and Brightens With Dual AHA Exfoliation

    Thinning and hormonally aging skin often accumulates dullness, uneven tone, and surface texture changes as cell turnover slows. FF3 Biointensive GF contains both mandelic and lactic acid that work together to gently resurface the skin, clear accumulated dead cell buildup, fade discoloration, and reveal a brighter, more even complexion. The dual AHA approach produces progressive improvement in clarity and luminosity with consistent use.

  • Vivant

    FF3 Triple Repair Complex

    $258.00

    GFP Complex with Retinyl Propionate, brightening peptides, and lactic acid for photo-aged, textured skin.

    If you have strong pigmentation and aging skin and your other products just aren't cutting it, this is where we would go. Fine lines, wrinkles, uneven tone, rough texture, all the signs of sun damage, FF3 Triple Repair Complex addresses them together. It's not the gentle option, it's the effective one. You will likely peel a bit and your skin may feel a little sensitive as it adjusts, which is completely normal. If you're combination to oily, you'll be fine. If you're on the drier side, introduce it slowly. And if you find your skin feeling a little reactive, adding Vivant Totaloe on top really helps counter that without interfering with the formula. What we really appreciate about this one is that it changes how your skin actually behaves over time and helps prevent new pigmentation from forming, not just fade what's already there.

    Laziza SFounder & Head Esthetician

    Retinyl Propionate and Growth Factors Repair Photo-Aged Skin

    Photo-aged skin carries years of accumulated structural damage. Triple Repair Complex delivers the proprietary GFP Complex, combining phyto-derived growth factors and Retinyl Propionate, to catalyze intensive cellular renewal, rebuild collagen, and restore the skin's structural integrity. In as little as two months of consistent nighttime use, skin shows visible improvements in tone, texture, firmness, dark spots, and deep wrinkles.

    Brightens and Fades Dark Spots and Hyperpigmentation

    Sun-induced hyperpigmentation, dark spots, and blotchy discoloration are among the most stubborn visible signs of cumulative photo-damage. Triple Repair Complex targets this through Oligopeptide-68, a skin brightening peptide that helps regulate melanin production, alongside lactic acid that resurfaces the skin and accelerates the clearance of discolored surface cells. Together they produce measurable improvements in the evenness and clarity of the complexion with consistent nightly use.

    Resurfaces and Smooths Rough Texture With Lactic Acid

    Rough, uneven texture in mature and photo-aged skin comes from years of slowed cell turnover and surface buildup. Lactic acid in Triple Repair Complex works at the chemical level to dissolve this buildup, resurface the skin, and reveal smoother, more radiant skin beneath. It also improves moisture retention at the surface, so skin feels more hydrated alongside the exfoliation.

    Firms and Reduces the Appearance of Wrinkles

    Triple Repair Complex addresses fine lines and wrinkles through two distinct mechanisms working together. Retinyl Propionate stimulates collagen production and accelerates cell renewal, while the Matrixyl 3000 peptide blend repairs the extracellular matrix responsible for skin firmness and structural integrity. Together they address both the cause and the appearance of wrinkles more fully than either active could achieve alone.

  • Calecim

    Hair Serum

    4.9 out of 5.0 stars

    $360.00

    Derma stamper and non-sticky serum with PTT-6® protein blend for thicker hair and scalp health.

    Calecim Hair Serum is one of our best selling hair serums at the clinic and there is a reason for that. What we consistently notice with clients who follow the 6 week protocol is baby hairs growing back at the hairline, hair that feels noticeably denser, and hairdressers commenting on the difference without being told. It also works well for hormonal and stress related hair loss, which is where a lot of our clients are. Results are not overnight and they work best when the follicles are still active, so starting sooner rather than later makes a difference. Consistency with the protocol is everything.

    Laziza SFounder & Head Esthetician

    Clinically Proven Support for Thinning Hair

    CALECIM Hair Serum is a growth-factor-rich topical solution designed to improve hair density, strength, and scalp health. Backed by clinical trials and powered by stem cell science, this formula targets hair thinning at the follicular level, helping to stimulate visibly thicker, fuller hair over time, without hormones or drugs.

    Powered by Stem Cell-Derived Growth Factors

    Formulated with CALECIM’s patented Rejuvenating Conditioned Media, the Hair Serum delivers a potent mix of growth factors, cytokines, and exosomes derived from umbilical cord lining stem cells. These biologically active proteins support scalp rejuvenation, strengthen hair anchoring, and create a healthier environment for hair regrowth.

    Professional Results, No Downtime

    Used in-clinic and at home, this system is ideal for men and women experiencing early to moderate hair thinning. It is often applied post-microneedling or in conjunction with in-office treatments like PRP or laser therapy to boost effectiveness. Results include improved hair volume, reduced shedding, and visibly healthier scalp skin.

    Easy Application, No Mess or Odor

    The lightweight serum absorbs quickly into the scalp without residue. It is drug-free, fragrance-free, and requires no special preparation. With just a few applications a week, CALECIM Hair Serum delivers science-backed results with minimal effort and no lifestyle disruption. Use half an ampoule per session with the derma stamper, aiming for one full ampoule each week.

  • Plated

    Intense Serum

    4.9 out of 5.0 stars

    From $244.00

    A watery exosome serum that targets wrinkles, laxity, discoloration, and acne scars with firming support.

    If you’re dealing with deeper wrinkles, laxity, or stubborn discoloration, plated INTENSE is the serum we recommend. It feels super light and delivers powerful results, supporting collagen, firming the skin, and helping smooth out scars or uneven tone. It’s advanced anti-aging care without feeling heavy, and our clients love how quickly their skin looks stronger and more refined.

    Laziza SFounder & Head Esthetician

    Intensive Regeneration for Aging Skin

    Intense Serum is designed for those who want serious age-reversing results. It delivers targeted support to visibly improve deep lines, sagging, rough texture, and uneven tone. This advanced formula goes beyond maintenance to restore what time and daily stress have taken away from the skin.

    Supercharged with Renewosome™ Technology

    Powered by plated's highest concentration of Renewosome exosomes, this serum delivers over 800 growth factors and skin-signaling molecules to encourage deep repair. These lab-designed exosomes mimic the body's own regenerative messengers to promote smoother, firmer, more youthful-looking skin. Panthenol and amino acids add soothing hydration and barrier support alongside the exosomes.

    Rebuilds Skin Resilience Over Time

    With continued use, Intense Serum visibly improves skin elasticity, reduces the look of wrinkles, and supports long-term collagen production. The formula strengthens the skin barrier and boosts cellular turnover, helping to refresh dull or fatigued skin from within. Apply it to clean skin as the very first step and let it absorb for five to ten minutes.

    Ideal for Advanced Correction and Recovery

    Recommended for mature or aging skin, this potent serum is also a strong choice post-procedure to support healing and recovery. It is non-comedogenic, fragrance-free, and hypoallergenic, making it safe for sensitive or reactive skin while supporting skin regeneration. It also helps smooth the look of scars and uneven tone with a light, weightless feel.

  • Calecim

    Multi-Action Cream

    5.0 out of 5.0 stars

    $200.00

    Rich cream that smooths texture, boosts firmness, and hydrates deeply for multiple aging concerns.

    We recommend Calecim Multi-Action Cream to anyone who wants firmer, lifted skin and a more youthful look. It works wonders on deep wrinkles and sagging, while restoring volume and evening out skin tone for that super glow. Most people see a visible difference in just a couple of weeks. Because it works like a serum, we suggest layering it under your moisturizer for the best results.

    Laziza SFounder & Head Esthetician

    Visibly Rebuild and Rejuvenate Aging Skin

    CALECIM Multi-Action Cream is an intensive anti-aging formula designed to firm, plump, and refine mature or thinning skin. With powerful stem cell-derived proteins, it supports collagen production, smooths deep lines, and restores facial fullness, leaving skin visibly lifted, hydrated, and more resilient with every application.

    Stem Cell Technology for Comprehensive Renewal

    This formula features CALECIM’s patented Rejuvenating Conditioned Media, rich in growth factors, cytokines, and peptides derived from umbilical cord lining stem cells. These biologically active ingredients work deep within the skin to encourage cellular repair, rebuild dermal structure, and improve elasticity, targeting multiple signs of aging at once.

    Ideal for Daily Use or Post-Procedure Recovery

    Multi-Action Cream is gentle enough for everyday use yet powerful enough to support healing after aesthetic procedures like laser or chemical peels, following your provider's aftercare. After microneedling, wait forty-eight hours before using it. It helps reduce redness, accelerates recovery, and enhances long-term results by promoting optimal skin regeneration.

    Lightweight Comfort, Maximum Impact

    Despite its rich benefits, the cream has a fast-absorbing, non-greasy texture that layers well with other products. Free from fragrances and parabens, it is suitable for all skin types, including sensitive, and delivers visible improvements in skin volume, smoothness, and radiance over time. Linoleic acid and vitamin E add barrier support and help skin hold on to moisture.

  • Pavise

    Precision Eye Lift

    4.7 out of 5.0 stars

    $128.00

    Firms, lifts, and brightens the eye area while reducing puffiness and smoothing fine lines.

    Pavise Precision Eye Lift does exactly what it promises, lifts, firms, and brightens the eye area with noticeable results. I personally tested this cream before its launch and saw a visible difference within just a couple of weeks. The formula is packed with powerful ingredients that smooth fine lines, tighten crepey skin, and restore a more refreshed, youthful look. It’s safe to use all around the eyes, including the eyelids, with no irritation. If you're looking for an eye cream that truly performs, this is one of our top picks for aging eyes.

    Laziza SFounder & Head Esthetician

    Lift, Brighten, and Smooth

    Precision Eye Lift delivers targeted care to the delicate eye area, visibly lifting, firming, and smoothing the skin. This concentrated formula reduces the appearance of fine lines, puffiness, and fatigue to reveal brighter, more youthful-looking eyes. Divide one pump between both eyes, applying it under the eyes, across the lids, and along the orbital bone up to the temples.

    Engineered for the Thinnest Skin on the Face

    The eye contour is one of the first areas to show signs of aging. Pavise's formulation supports microcirculation and reinforces the skin's natural structure, helping to minimize dark circles and under-eye bags. The lightweight texture absorbs quickly and layers well with makeup. Growth factors help support collagen production and elasticity in this delicate area.

    DiamondCore® Tech Meets Peptide Power

    This formula combines Pavise’s patented DiamondCore zinc oxide with a potent peptide complex to protect against environmental stress and encourage collagen synthesis. DiamondCore is a modified diamond molecule engineered for broad-spectrum UV protection with less heat absorption and free radical formation. It strengthens the skin's natural defense while working to smooth wrinkles and improve elasticity over time.

    Designed for Daily Resilience

    Precision Eye Lift is ophthalmologist-tested and safe for twice-daily use. Whether you are tackling early signs of aging or want a preventative boost, it fits seamlessly into any routine. It is formulated for sensitive eyes and powerful enough to make a visible impact. It can be used on the eyelids as well as under the eyes.

  • Calecim

    Professional Pigment Solution

    5.0 out of 5.0 stars

    $148.00

    High-potency serum with PTT-6 plus pigment-fading actives to reduce dark spots and even skin tone.

    We think Calecim Professional Pigment Solution is so unique because it tackles both pigmentation and signs of aging at the same time. Our clients love it, whether they’re dealing with dark spots and wrinkles, or acne scars with leftover pigmentation. It’s truly like a two-in-one solution that brightens and rejuvenates the skin.

    Laziza SFounder & Head Esthetician

    Brighten and Even Your Skin Tone

    CALECIM Professional Pigment Solution targets stubborn discoloration, including sun damage, melasma, post-inflammatory hyperpigmentation, and uneven skin tone. Formulated without hydroquinone or retinoids, it is a gentle yet powerful serum that restores clarity and radiance for visibly brighter, more even-toned skin with no downtime. Use it morning and night across areas of uneven tone, adding a second layer on stubborn spots.

    Advanced Science for Fading Dark Spots

    This formula harnesses CALECIM’s proprietary stem cell-derived proteins, combined with proven brightening agents, to address pigmentation at the source. It works by calming inflammation, suppressing melanin overproduction, and strengthening the skin barrier, making it ideal for clients who have not responded well to other brightening products.

    Safe for All Skin Types and Tones

    Pigment Solution is suitable for daily use and safe for long-term maintenance. Free of hydroquinone, steroids, and exfoliating acids, it is well suited to sensitive, dry, and reactive skin types. It can also be used post-procedure to minimize pigmentation flare-ups and support skin healing. The formula contains no alcohol, fragrance, parabens, or silicone, which suits easily irritated skin.

    Clinical Results, Professional Confidence

    Used and recommended by aesthetic providers, this solution has been clinically tested to improve discoloration, even tone, and restore skin luminosity over time. With consistent use, most users see visible improvement in pigmentation within 8 to 12 weeks. It also addresses early signs of aging, so it works as a two-in-one brightening and rejuvenating step for dark spots, fine lines, and lingering acne marks.

  • Calecim

    Professional Serum

    4.8 out of 5.0 stars

    $100.00

    Concentrated stem cell serum with PTT-6® that renews skin, boosts firmness, and improves radiance.

    We and our clients are truly obsessed with the Calecim Professional Serum. It’s such a game-changer for recovery; we have seen it cut downtime after procedures (even CO₂ lasers) in half. It calms the skin, helps it bounce back faster, and makes such a difference with wrinkles, elasticity, and even acne scarring. Some use it daily, others just after procedures depending on their budget, but either way the results are amazing.

    Laziza SFounder & Head Esthetician

    Fast-Track Healing and Rejuvenation

    CALECIM Professional Serum is a potent, stem cell-based formula designed to accelerate skin recovery after in-office procedures. It reduces redness, calms inflammation, and supports faster healing while boosting skin quality. With consistent use, it visibly improves firmness, tone, and texture, making it ideal for both recovery and long-term rejuvenation.

    A High Concentration of Stem Cell Proteins

    This serum contains the most concentrated dose of CALECIM’s patented Rejuvenating Conditioned Media, rich in growth factors, cytokines, and peptides derived from umbilical cord lining stem cells. These biologically active molecules stimulate repair, promote collagen synthesis, and help restore the skin’s structural integrity from within.

    Post-Procedure Essential

    Trusted by medical professionals, CALECIM Professional Serum is widely used after laser, chemical peels, and other skin-resurfacing procedures. It calms and nourishes compromised skin, minimizes downtime, and enhances procedure outcomes, helping you see results sooner, with less discomfort and inflammation. After microneedling, wait forty-eight hours before using it, unless your provider gave you specific aftercare for that window.

    Lightweight and Compatible with All Skin Types

    Despite its high potency, the serum is lightweight, non-comedogenic, and absorbs quickly. It is safe for sensitive, post-procedure, and even acne-prone skin. Free from fragrance, parabens, and synthetic additives, it integrates seamlessly into any recovery or anti-aging regimen. For everyday anti-aging care, apply one pipette to the entire face before your other creams.

  • Calecim

    Recovery Night Complex

    5.0 out of 5.0 stars

    $115.00

    Overnight gel mask that reduces redness, repairs damage, and supports collagen renewal while you sleep.

    Calecim Recovery Night Complex is essential for anyone with dryness or sensitivity, and it delivers incredible anti-aging benefits too. This lightweight gel deeply hydrates, calms, and supports repair while you rest. Our clients love how much softer and more revitalized their skin feels, and many start noticing fewer visible signs of aging in as little as 2 to 3 weeks.

    Laziza SFounder & Head Esthetician

    Overnight Recovery for Stressed, Compromised Skin

    Recovery Night Complex is a professional-grade overnight gel that supports deep hydration, calms inflammation, and enhances visible skin recovery while you sleep. Ideal for post-procedure care or stressed skin, this cooling gel formula creates a breathable “second skin” layer to lock in healing and hydration all night long.

    Designed for Post-Procedure and Sensitized Skin

    Formulated to support skin that has been compromised by in-office procedures, environmental stress, or barrier damage, Recovery Night Complex contains calming peptides and hydrating agents that soothe, protect, and accelerate renewal. It helps reduce redness, tightness, and discomfort after laser or peels, following your provider's aftercare. After microneedling, wait forty-eight hours before using it, unless your provider gave you specific aftercare for that window.

    Stem Cell Science Meets Skin Recovery

    At the heart of this formula is CALECIM’s proprietary Rejuvenating Conditioned Media, a stem cell-derived blend of peptides, growth factors, and cytokines that promote repair and rebuild skin structure. Combined with moisture-locking ingredients, it restores skin’s resilience overnight and enhances long-term recovery outcomes. Cucumber extract adds calming, cooling, and anti-inflammatory support for sensitive or irritated skin.

    Lightweight, Breathable, and Non-Sticky

    Despite its intensive benefits, Recovery Night Complex is oil-free and fast-absorbing, with a weightless gel texture that does not clog pores or feel heavy. It is suitable for all skin types, including oily or breakout-prone skin, and can be used after a laser or peel as your provider directs, or during flare-ups of sensitivity.

  • Marini SkinSolutions

    Regeneration Booster

    $248.00

    Growth factor and peptide serum that firms, smooths, and regenerates.

    Regeneration Booster from Marini SkinSolutions is one of those products we recommend when a client's skin needs more than what a standard anti-aging routine is giving them. Growth factors are not an ingredient most people know to look for, but the results speak for themselves. What we love about this one is that it addresses so many concerns at once and there is zero irritation, which means it works for all skin types including sensitive.

    Laziza SFounder & Head Esthetician

    Addresses Multiple Signs of Aging at Once

    Marini SkinSolutions Regeneration Booster is a patented growth factor and peptide formula that supports the skin's own regeneration processes to visibly reduce signs of aging. In an independent physician study, 100% of subjects showed improvement across wrinkles, texture, pore size, elasticity, clarity, and hydration. It is suitable for all skin types and works at any stage of an anti-aging routine.

    What Growth Factors Are and Why They Matter

    Growth factors are proteins that occur naturally in the skin and play a central role in cellular repair and regeneration. They signal skin cells to produce collagen, renew themselves, and keep skin firm, smooth, and resilient. This activity slows with age, and Regeneration Booster delivers a concentrated blend of clinically studied growth factors that support these processes directly.

    Firms Skin and Reduces Fine Lines and Wrinkles

    When the skin's repair and collagen-building processes are well supported, fine lines fill in gradually. Regeneration Booster pairs growth factors with seven peptides that signal collagen and elastin production, improve elasticity, and reduce the depth of fine lines and wrinkles over time. In the clinical study, 94% of subjects reported superior satisfaction in skin quality after three months.

    Addresses Crepey Skin and Under-Eye Circles

    Crepey skin and under-eye circles involve both a loss of hydration and structural thinning. Regeneration Booster pairs its growth factors with ceramides, shea butter, mango seed butter, and hyaluronic acid, so it hydrates deeply while supporting the cellular repair that improves skin density. With consistent use, skin looks more supple, and crepey texture and under-eye circles appear softer.

  • Hydrinity

    Restorative HA+ Mask

    4.4 out of 5.0 stars

    $120.00

    Recovery sheet mask that hydrates deeply, calms stressed or post-procedure skin, and speeds healing.

    The HA Mask is a client favorite for good reason; it instantly soothes and deeply hydrates the skin, leaving it looking radiant, refreshed, and noticeably smoother within minutes. It’s a go-to post-treatment or whenever the skin needs a calming reset. Clients love how it reduces redness, softens the look of fine lines, and gives the skin that healthy, plump glow. It's more than a sheet mask, it's a treatment.

    Laziza SFounder & Head Esthetician

    Deep Recovery Meets Intensive Hydration

    Hydrinity’s Restorative HA+ Mask is a bio-cellulose sheet mask that delivers immediate calming, plumping, and repair for stressed skin. It is designed to soothe irritation, restore hydration, and strengthen the barrier, making it perfect for recovery after procedures or whenever skin needs a boost of comfort and resilience.

    Supports Skin Repair and Recovery

    Epidermal growth factors (including Oligopeptide-1) stimulate cellular regeneration, helping the skin heal from daily stress, post-procedure sensitivity, and environmental aggressors. Urea, allantoin, and sodium hyaluronate provide multi-layered moisture to soothe irritation and restore suppleness. Apply the sheet mask to a clean face one to two times per week for calming and recovery.

    Boosts the Skin Barrier

    Ceramides NP, AP, and EOP work in harmony with cholesterol and phytosphingosine to strengthen the skin’s protective barrier, lock in hydration, and reduce trans-epidermal water loss. This is especially beneficial for dry, inflamed, or compromised skin that needs extra support. The result is skin that feels calmer, softer, and better protected against environmental stress.

    Postbiotic Blend for Resilient Skin

    Lactobacillus, bifida, and lactococcus ferment lysates help calm inflammation, improve the skin’s microbiome health, and reinforce its natural defenses, which supports clear, balanced, and radiant skin. Oligopeptide-1, a growth factor, supports regeneration and speeds recovery after stress or procedures, while the calming, hydrating formula helps soften the look of fine lines and visible redness.

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